Type 1: The middle and lower thirds of the esophagus: Small, punched-out lesions with raised margins; a slightly yellowish color and fibrin exudation at the center of lesions

Type 2: The middle and lower thirds of the esophagus: Small, punched-out lesions without raised margins; no color and no exudation

Type 3: Multiple ulcers become confluent, like a map at the extended esophageal lesions

Initial treatment

•Biopsy: Histological identification of HSV for ∆+

•Blood tests: Serological HSV anti IgM, anti-HSV IgG

•Others test: Immunodeficiency, renal failure, malignancy, transplanted organs, HIV, steroid or immunosuppressive therapy

•Therapy: Antivirus (Acyclovir, Famciclovir, Valacyclovir)